Plots of energy vs rmsd from the native structure for the 1LQ7 protein generated using multiplexed-replica exchange MD simulations with different numbers of replicas. The number of replicas is shown in top-left corner of each graph. The total length of the simulation is the same for all graphs. Different colors from the rainbow spectrum represent different temperatures: red for 300 K, orange for 350 K, green for 400 K, cyan for 500 K, blue for 600 K, and magenta for 700 K.