Figure 1. Folate Pathway in Humans.
Substrates are shown in rectangular boxes. DHF: dihydrofolate; Hcy: homocysteine; MET: methionine; SAM: S-Adenosyl-methionine; SAH: S-Adenosylhomocysteine; THF: tetrahydrofolate
Enzymes are shown in ellipses. ACHY: S-adenosylhomocysteine hydrolase; BHMT: betaine-homocysteine methyltransferase; CBS: cystathionine-β-synthase; DHFR: dihydrofolate reductase; MAT2A: methionine adenosyltransferase II alpha; MAT2B: methionine adenosyltransferase II beta; MTHFD1: methylenetetrahydrofolate dehydrogenase; MTHFR: methylenetetrahydrofolate reductase; MTR: methyltetrahydrofolate-homocysteine methyltransferase; MTRR: MTR reductase; TYMS: thymidylate synthase; MT: methyl-transferases