Table 2.

SNPs Genotyped

Gene				Putative
Symbol	Gene Name	SNP ID	Chromosome	Function
AHCY	S-adenosylhomocysteine	rs819146	20	Promoter
	hydrolase	rs819156		Intron 3
		rs7271501		Intron 6
		rs819133		Intron 9
BHMT	betaine-homocysteine	rs16876512	5	Promoter
	methyltransferase	rs3733890		R239Q, ESE
		rs4703772		L264, ESE
		rs585800		3′-UTR, ESE
CBS	cystathionine-b-synthase	rs1788484	21	Promoter
		rs5742905		I278T, ESE
		rs12613		3′-UTR, ESE
		rs706209		3′-UTR, ESE
DHFR	dihydrofolate reductase	rs408626	5	Promoter
		rs1677658		Promoter
		rs1643649		Intron
MAT2A	methionine adenosyltransferase	rs1078004	2	R264, ESE
	II alpha	rs2043675		Intron 7
MAT2B	methionine adenosyltransferase	rs4869087		Intron 1
	II beta	rs12515448		Intron 2
		rs17061795		L175, ESE
		rs6898075		Intron 4
MTHFD1	methylene-tetrahydrofolate	rs8003379	14	Intron 2
	dehydrogenase	rs1950902		K134R
		rs8016556		Intron 16
		rs11627387		Intron 26
		rs2281603		Intron 27
MTHFR	methylene-tetrahydrofolate	rs3737965	1	Promoter
	reductase	rs2066470		P39, ESE
		rs9651118		Intron 2
		rs2066462		S352, ESE
		rs2274976		R594Q, ESE
		rs4846049		3′-UTR
MTR	methyltetrahydrofolate-	rs1805087	1	D919G, ESE
	homocysteine	rs2229276		A1048, ESE
	methyltransferase	rs1131449		L1192, ESE
		rs11799670		3′-UTR, ESE
MTRR	methyltetrahydrofolate-	rs326118	5	Promoter
	homocysteine	rs1532268		S175L
	methyltransferase reductase	rs10064631		L333V, ESE
		rs162036		K350R, TRP
		rs2287780		R415C
		rs16879334		P450R, ESE
		rs9282787		3′-UTR ESE
		rs9282788		3′-UTR ESE
		rs9332		3′-UTR ESE
TYMS	thymidylate synthase	rs2853533	18	Intron 1
		rs699517		3′-UTR ESE
		rs2790		3′-UTR ESE

SNP: single nucleotide polymorphism, ESE: exonic splicing element, UTR: mRNA untranslated region, TRP: triple helix regulatory site, rs: reference SNP