Table 2.
Allelic association of FOXO1A and FOXO3A with longevity (sex-combined in Population 1)
| SNP | Allele (major/minor) | Function | MAF (case/control) | PHWT | OR (95% CI) | P | bP | PW (α = 0.05) |
|---|---|---|---|---|---|---|---|---|
| rs17630266 | G/T | Intronic | 0.392/0.372 | 0.50 | 1.09(0.95–1.25) | 0.221 | 0.221 | NC |
| rs2755209 | C/T | Intronic | 0.242/0.286 | 0.86 | 0.80(0.69–0.93) | 4.6 × 10−3 | 9.0 × 10−3 | 0.83 |
| rs2755213 | C/T | Intronic | 0.352/0.420 | 0.53 | 0.75(0.65–0.86) | 7.4 × 10−5 | 3.0 × 10−4 | 0.98 |
| rs2253310 | G/C | Intronic | 0.303/0.244 | 0.70 | 1.35(1.16–1.57) | 7.9 × 10−5 | 2.3 × 10−4 | 0.97 |
| rs2802292 | T/G | Intronic | 0.302/0.240 | 0.74 | 1.36(1.18–1.60) | 2.9 × 10−5 | 1.5 × 10−4 | 0.98 |
| rs4946936 | C/T | 3′-UTR | 0.283/0.221 | 0.40 | 1.40(1.19–1.64) | 1.8 × 10−5 | 1.1 × 10−4 | 0.99 |
MAF, minor allele frequency; PHWT, P-value from Hardy–Weinberg equilibrium test; OR (95% CI), odds ratio with 95% confidence interval; P, P-value calculated from χ2 test; bP, corrected P by Bonferroni step-down method; PW, power to reach an alpha level of 0.05 with a given population size; NC, not calculated; 3′-UTR, 3-untranslated region.