(A) Fed and fasting blood glucose levels (left) and glucose tolerance (right) in LKB1lox/lox and PLKB mice (n = 11 mice per genotype). Mice were injected with tamoxifen at 4 weeks of age, and assays were performed 1 week later.
(B) Insulin sensitivity in LKB1lox/lox and PLKB mice (n = 9 mice per genotype). Same mice were used as in (A).
(C) Serum insulin levels 15 min after the injection of glucose to LKB1lox/lox and PLKB mice (n = 7 mice per genotype). Mice were injected with tamoxifen at 4 weeks of age, and assay was performed 1 month later. Error bars represent standard deviations. **p < 0.01.