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. Author manuscript; available in PMC: 2009 Dec 8.
Published in final edited form as: Mutat Res. 2006 Nov 20;627(1):92–105. doi: 10.1016/j.mrgentox.2006.10.006

Table 1.

Activity of urethane in the mouse bone marrow micronucleus test

Agent Dose (mg/kg) Route PCE/NCE ratio (±S.D.) MNPCE/1000 PCE (±S.D.)
Vehicle control – Oral 1.1 (0.05) 2.6 (1.6)
– i.p. 1.05 (0.08) 2.9 (0.9)
Urethane 900 Oral 0.66 (0.09) 62.2 (10.8)
900 i.p. 0.55 (0.05) 67.9 (11.0)

Data taken from Ashby et al. [8]. Assay was carried out in male CBA mice; bone marrow was sampled 24 h after dosing. i.p.: intraperitoneal; PCE: polychromatic erythrocyte; NCE: normochromatic erythrocyte; MNPCE: micronucleated PCE.