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Bone marrow micronucleus assay of compound B kinase inhibitor in the rat
| Compound B dose (mg/(kg day)) | MNPCE/1000 PCE’s | PCE/NCE ratioa |
|---|---|---|
| 0 (vehicle control, 3 rats) | 1.0 | 1.20 (range 0.93–1.50) |
| 12.5 | 1.5 | 0.46 |
| 25 | 1.0 | 1.10 |
| 50 | 1.5 | 0.89 |
| 100 | 10.5 | 0.27 |
| 200 | 6.5 | 0.43 |
Three daily oral gavage doses, sacrificed 6 h after last dose; except as noted, single rat per dose level; 2000 PCEs scored per rat. PCE: polychromatic erythrocyte; MNPCE: micronucleated PCE.
Statistical analysis not provided.
