Table 11.
Rat bone marrow micronucleus test with pharmacia compound X
| Treatment | Dose | MNPCE/1000 PCE (±S.D.) | PCE:NCE (±S.D.) |
|---|---|---|---|
| Vehicle | Methylcellulose | 1.1 (0.02) | 0.98 (0.07) |
| Cyclophosphamide (positive control) | 60 mg/kg | 21.7a (0.24) | 0.79 (0.06) |
| Compound X | 250 mg/(kg day) | 1.8a (0.02) | 1.06 (0.04) |
| 500 mg/(kg day) | 2.2a (0.03) | 1.14 (0.06) | |
| 1000 mg/(kg day) | 2.5a (0.02) | 1.04 (0.06) |
PCE: polychromatic erythrocyte; NCE: normochromatic erythrocyte; MNPCE: micronucleated PCE.
a
Significantly greater than corresponding vehicle control, p < 0.05.