Table 12.

Mouse bone marrow micronucleus test of Roche tubulin inhibitor, compound 1

Agent	Dose (mg/kg)	PCE/NCE ratio	MNPCE/1000 PCE
Vehicle control	0	1.82	1.0
Compound 1	1.0	0.50	8.5^a
	2.0	0.42	5.0^a
	4.0	0.18	5.0^a
Colcemid (positive control)	2.5	0.75	10.7^a

Mice were given single i.v. doses (apart from the positive control which was dosed orally), and the bone marrow harvested 24 h later. PCE: polychromatic erythrocyte; NCE: normochromatic erythrocyte; MNPCE: micronucleated PCE.

p < 0.01.