Table 13.

Bone marrow micronucleus tests of AstraZeneca compound C in male rats

Compound C oral dose (mg/kg)	MNPCE/1000 PCE
	Test 1	Test 2	Test 3
0.0 (vehicle control)	0.7	0.7	1.1
0.8			0.9
2.5			0.5
8		1.5^a	0.9
25		2.4^a
76	1.8^a	2.7^a
380	2.5^a
760	2.4^a

All results 24 h after oral dosing (2000 PCE scored); no increases seen after 48 h. No evidence of aneugenicity (increased kinetochore-staining micronuclei). PCE: polychromatic erythrocyte; MNPCE: micronucleated PCE.

p < 0.001.