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. Author manuscript; available in PMC: 2009 Dec 8.
Published in final edited form as: Mutat Res. 2006 Nov 20;627(1):92–105. doi: 10.1016/j.mrgentox.2006.10.006

Table 2.

Mouse peripheral blood micronucleus test of salicylazosulfapyridine (SASP)

Agent Dose (mg/kg) MNPCE/1000 PCE (±S.D.) MNNCE/1000 NCE (±S.D.)
Vehicle control – 1.71 (0.32) 1.07(0.08)
SASP 675 2.27 (0.42) 2.46a(0.17)
1350 3.42a (0.45) 2.94a (0.22)
2700 3.66a (0.41) 2.78a (0.20)

Data from male B6C3F1 mice (five per group); peripheral blood was obtained at the termination of a 90-day oral gavage NTP toxicity study. At least 2000 PCEs and 10,000 NCEs from each animal were scored for micronuclei [17]. PCE: polychromatic erythrocyte; NCE: normochromatic erythrocyte; MNPCE: micronucleated PCE; MNNCE: micronucleated NCE.

a

p <0.01, Cochran–Armitage test.