Table 4.
Mouse bone marrow micronucleus test of Alimta®
| Agent | Dose (mg/kg) | PCE/NCE ratio (±S.D.) | MNPCE/1000 PCE (±S.D.) |
|---|---|---|---|
| Vehicle control | – | 1.2 (0.3) | 1.2 (1.1) |
| Alimta® | 393.5 | 1.1 (0.4) | 5.0 (2.4) |
| 787.1 | 0.7 (0.2) | 4.8 (2.2) | |
| 1574.1 | 0.8 (0.1) | 4.3a (2.2) | |
| Cyclophosphamide (positive control) | 25.0 | 1.0 (0.2) | 16.4 (1.5) |
Two equal i.v. doses were given 24 h apart to ICR mice, with harvest 24 h after the second treatment. Male mouse data shown (five per group); similar results obtained in female mice. PCE: polychromatic erythrocyte; NCE: normochromatic erythrocyte; MNPCE: micronucleated PCE.
a
p = 0.02, treated groups were significantly increased relative to the vehicle control as determined by a two-tailed trend test.