Table 5.
| Table 5a Rat bone marrow micronucleus test of Pfizer MEK kinase inhibitor 1 (MEK1) in male animals | |||
|---|---|---|---|
| Agent | Dose (mg/kg) | PCE/NCE ratio | MNPCE/1000 PCE (±S.D.) |
| Vehicle control | –a | 7.3 | 2.0 (0.82) |
| MEK1 | 0.3 | 11.5 | 1.8 (0.84) |
| 1.0 | 8.1 | 1.8 (0.45) | |
| 3.0 | 10.0 | 3.2 (1.3) | |
| Cyclophosphamide (positive control) | 20.0 | 5.3 | 5.8 (1.1) |
| Table 5b Rat bone marrow micronucleus test of Pfizer MEK kinase inhibitor 1 (MEK1) in female animals | |||
|---|---|---|---|
| Agent | Dose (mg/kg) | PCE/NCE ratio | MNPCE/1000 PCE (±S.D.) |
| Vehicle control | –a | 5.7 | 2.4 (1.1) |
| MEK1 | 0.3 | 6.1 | 2.2 (0.8) |
| 1.0 | 5.3 | 2.8 (0.45) | |
| 3.0 | 5.3 | 5.4b (1.1) | |
| Cyclophosphamide (positive control) | 20.0 | 2.1 | 10.8b (2.4) |
Doses were administered to groups of five Sprague–Dawley rats once daily for 2 days by oral gavage and the bone marrow harvested 24 h after the final dose. PCE: polychromatic erythrocyte; NCE: normochromatic erythrocyte; MNPCE: micronucleated PCE.
a
0.5% methylcellulose/0.2% Tween 80 in water.
b
Statistically significant, p < 0.05.