Table 7.
Rat bone marrow micronucleus test of Pfizer MEK kinase inhibitor 2 (MEK2)
| Agent | Dose (mg/kg) | PCE/NCE ratio | MNPCE/1000 PCE (±S.D.)a |
|---|---|---|---|
| Vehicle | –b | 2.7 | 4.4 (0.6) |
| MEK2 | 50 | 4.0 | 4.2 (1.2) |
| 100 | 2.3 | 11.8 (2.8) | |
| 300 | 1.0 | 17.5 (2.4) | |
| Cyclophosphamide (positive control) | 20 | 1.9 | 13.0 (1.1) |
Doses were administered to groups of five Sprague–Dawley rats once daily for 2 days by oral gavage and the bone marrow harvested 24 h after the final dose. Data from male animals shown; female animals gave comparable results. PCE: polychromatic erythrocyte; NCE: normochromatic erythrocyte; MNPCE: micronucleated PCE.
a
Statistical analysis not provided.
b
0.5% methylcellulose/0.2% Tween 80 in water.