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. Author manuscript; available in PMC: 2009 Dec 8.
Published in final edited form as: Mutat Res. 2006 Nov 20;627(1):92–105. doi: 10.1016/j.mrgentox.2006.10.006

Table 9.

Mouse micronucleus assay of Merck compound B kinase inhibitor

Agent Dose (mg/kg) 24 h
 48 h
PCE/NCE ratio MNPCE/1000 PCE PCE/NCE ratio MNPCE/1000 PCEa
Solvent control 0 0.73 1.7 0.96 1.5
Compound B 50 0.30 23.0 0.05 19.3
100 0.13 37.9 0.06 53.2
200 0.13 29.8 0.05 57.4
Mitomycin C (positive control) 2.0 0.90 59.5 – –

Mice were dosed orally in groups of five males; one set of groups was killed 24 h after dosing, the second set after 48 h. 2000 PCEs scored for micronuclei. PCE: polychromatic erythrocyte; MNPCE: micronucleated PCE.

a

Statistical analysis not provided.