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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Curr Opin Struct Biol. 2009 Nov 14;19(6):650–657. doi: 10.1016/j.sbi.2009.10.017

Figure 1. The PknB KD:ATPγS structure resembles the transition-state analog complex of cAMP-dependent protein kinase (PKA).

Figure 1

Superimposed backbone ribbons show the similarity of the classic kinase folds of PknB (blue) and PKA (yellow), including the two-domain structure and the P-loop covering the nucleotide. The bound nucleotides and several active-site residues in PknB:ATP-γ-S (blue) and the PKA:ADP:AlF3:peptide transition-state-analog complex [45] shows that conserved residues contact the nucleotides in similar conformations.