Table 4.

Regression analyses of age, genotype, and storage on PON1 enzyme activity in smaller age intervals.

	1 vs. 2 years of agea			5 vs. 7 years of ageb			5 vs. 7 years of age, interaction model
	β-Estimate	95% CI	p-Value	β-Estimate	95% CI	p-Value	β-Estimate	95% CI	p-Value
AREase
Intercept	42.3	4.7 to 79.9	0.027	21.5	−28.1 to 71.0	0.396	23.2	−30.1 to 76.5	0.39
Agec	21.0	11.8 to 30.2	< 0.001	14.9	8.2 to 21.6	< 0.001	14.6	7.1 to 22.1	< 0.001
PON1192d	−4.8	−8.8 to −0.7	0.022	−5.3	−9.0 to −1.7	0.004	−7.3	−27.9 to 13.2	0.48
Storage duratione	1.4	−4.4 to 7.1	0.643	−3.9	−12.8 to 4.9	0.384	−3.9	−12.7 to 5.0	0.39
Age × PON1192f							0.3	−3.1 to 3.7	0.85
CPOase
Intercept	3197.9	879.9 to 5515.9	0.007	1837.6	−985.3 to 4660.5	0.202	2356.9	−636.1 to 5349.9	0.12
Age	1288.9	712.0 to 1865.9	< 0.001	703.0	318.5 to 1087.5	< 0.001	617.4	197.9 to 1,036.9	< 0.001
PON1192	190.0	−58.2 to 438.3	0.133	188.5	−13.6 to 390.5	0.068	−412.0	−1644.7 to 820.7	0.51
Storage duration	−139.5	−492.2 to 213.3	0.438	−29.4	−542.0 to 483.2	0.911	−17.4	−530.5 to 495.8	0.95
Age × PON1192							96.7	−100.4 to 293.8	0.34
POase
Intercept	280.1	−80.4 to 640.6	0.128	−133.3	−528.7 to 262.0	0.509	76.1	−333.2 to 485.4	0.72
Age	128.0	23.6 to 232.3	0.016	67.1	13.8 to 120.5	0.014	32.6	−23.2 to 88.4	0.25
PON1192	412.9	366.6 to 459.2	< 0.001	535.3	501.6 to 568.9	< 0.001	293.1	86.4 to 499.8	0.01
Storage duration	−55.8	−109.0 to −2.6	0.04	6.8	−65.3 to 79.0	0.853	11.7	−59.9 to 83.2	0.75
Age × PON1192							39.0	6.7 to 71.3	0.02

^aThis model included 52 children 1 year of age and 249 children 2 years of age. Of these children, 35 had measurements at both time points.

^bThis model included 225 children 5 years of age and 281 children 7 years of age. Of these children, 189 had measurements at both time points.

^cAge was expressed in years.

^dPON1₁₉₂ was coded 0, 1, and 2 for QQ, QR, and RR genotypes, respectively.

^eStorage duration was expressed in years.

^fAge × PON1₁₉₂ refers to the interaction term between age and PON1₁₉₂ genotype.