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. Author manuscript; available in PMC: 2010 Nov 10.
Published in final edited form as: Eur J Pharmacol. 2009 Sep 14;622(1-3):15–24. doi: 10.1016/j.ejphar.2009.09.001

Fig. 2.

Fig. 2

EB rapidly modulates cannabinoid-induced changes in food intake and core body temperature. A, The dose-response effects of WIN 55,212-2. *, Values of food intake measured in animals treated with WIN 55,212-2 that are significantly different (multifactorial ANOVA/LSD; P<.05; n=4) than those measured in vehicle-treated controls. B, EB blocks the hyperphagic effect of WIN 55,212-2. *, Values of food intake measured in animals treated with WIN 55,212-2 that are significantly different (multi-factorial ANOVA/LSD; P<.05; n=4–7) than those measured in vehicle-treated controls. #, Values from EB-treated animals that are significantly different (multi-factorial ANOVA/LSD; P<.05; n=4–7) than those from their vehicle-treated counterparts. C, EB attenuates the hypothermic effect of WIN 55,212-2. *, Values from animals EB-treated animals that are significantly different (multi-factorial ANOVA/LSD; P<0.05; n=4–7) than those observed in vehicle-treated controls. D, Estrogen is without effect on the hypophagic effect of AM251. *, Values of food intake measured in AM251-treated animals that are significantly different (multi-factorial ANOVA/LSD; P<.05; n=4–7) than those measured in vehicle-treated controls. #, Values from EB-treated animals that are significantly different (multi-factorial ANOVA/LSD; P<.05; n=4–7) than those from their vehicle-treated counterparts. Columns represent the mean and vertical lines 1 S.E.M. of the food intake measured at 1, 2, 4, 8, 16 and 24 h for seven days in animals treated daily (8:00 a.m.) with WIN 55,212-2 (0.1–1 mg/kg; s.c.), AM251 (3 mg/kg; s.c.) or its cremephor/ethanol/saline vehicle, and every other day with EB (4–10 μg; s.c.) or its sesame oil vehicle. Symbols represent the means and vertical lines 2 S.E.M. of the core body temperature recorded every seven minutes by DataLoggers inserted into the abdominal cavity at the time of castration.