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. Author manuscript; available in PMC: 2009 Dec 8.
Published in final edited form as: Chem Rev. 1997 Aug 5;97(5):1473–1488. doi: 10.1021/cr9603791

Figure 9.

Figure 9

Examples of DNA analogues with amide bonds replacing phosphodiester bonds, in comparison to natural DNA (left). The amide linkage has restricted rotational freedom relative to the natural phosphodiester linkage. See ref 65.