Table 4.
Clinical Characteristics of COPDGene Subjects Stratified by Early Interstitial Lung Disease Status.*
| Characteristic | Score “0” (n=65) | Score “2” (n=10) | P Value† |
|---|---|---|---|
| Age (years) | 61 (56–65) | 64 (60–69) | 0.4 |
| Age Started Smoking | 17 (15–18) | 17 (14–18) | 0.8 |
| Gender (female) | 36 (55%) | 5 (50%) | 1.0 |
| Race (white) | 57 (88%) | 9 (90%) | 1.0 |
| COPD Diagnosis‡ | 16 (25%) | 3 (30%) | 0.7 |
| Current Smoker | 27 (42%) | 7 (70%) | 0.2 |
| Pack Years Tobacco | 33 (23–48) | 43 (33–90) | 0.05 |
| FEV1 % Predicted§ | 93 (77 – 108) | 82 (79 – 99) | 0.2 |
| FVC % Predicted§ | 101 (90 – 109) | 89 (86 – 102) | 0.2 |
| FEV1/FVC | 0.73 (0.61 – 0.82) | 0.69 (0.66 – 0.76) | 0.7 |
| 6 MWT (meters) | 1700 (1400–1861) | 1739 (1560–1780) | 0.7 |
A comparison of the differences in the clinical characteristics of subjects with CT findings suggestive of early ILD subjects and normal subjects from the COPDGene study identified by the consensus Chest CT reading method are presented. Median and interquartile ranges or numbers and percentages are presented where appropriate.
P values presented result from the comparison of early ILD status and normal subjects by Fisher Exact tests (for binary variables) and Wilcoxon Rank Sum tests (for continuous variables).
COPD was defined using modified Global Initiative for Chronic Obstructive Lung Disease (GOLD) Stage II criteria(24) (an FEV1/FVC ratio < 0.7 and an FEV1 < 80% of predicted).
Predicted values for FEV1 and FVC are derived from Hankinson et al.(25)