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. 2009 Dec 9;4(12):e8183. doi: 10.1371/journal.pone.0008183

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Schisler et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The analysis used to identify geo-ancestral genes involved three primary steps: 1) Significance of Microarray (SAM) analysis of two distinct populations in North Carolina, Americans of African or European ancestry, identified 2531 genes as differentially expressed between the populations (green); 2) The set of 2531 genes was further restricted to those genes than had SNPs that distinguished to representative ancestral populations from the HapMap project, a total of 897 genes (yellow); 3) Further restriction to only those genes that have an absolute mean fold change of 1.3 yielded the set of 151 geo-ancestral genes (purple). SNP graphic courtesy of David Hall.