Table 1.
Anti-HIV activity and inhibition on HIV-1 fusion core formation
| Compound | Anti-HIV activitya |
Inhibitory activityb EC50 (nM) | |||
|---|---|---|---|---|---|
| EC50 (nM) |
IC50 (nM) |
Fusion core formation 6HB (N36+C34) |
|||
| Syncytium | P24 | Cytotoxicity | N-PAGE | CDSA | |
| Ole | 55 ± 5 | 73 ± 8 | >10,000 | 66 ± 5 | 62 ± 6 |
| HT | 61 ± 6 | 68 ± 8 | >10,000 | 58 ± 8 | 60 ± 4 |
a
EC50, effective concentration at 50% inhibition; IC50, cytotoxicity concentration at 50% inhibition.
b
N-PAGE, native polyacrylamide gel electrophoresis; CDSA, circular dichroism spectroscopy analysis. Values are means ± SD of triplicates in three independent determinations.