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. 2009 Jan 6;17(3):417–424. doi: 10.1038/mt.2008.292

Figure 8.

Figure 8

Analysis of coagulation profile of mice receiving dual-chain vectors. The blood of mice receiving dual vector via intravenous injection was evaluated for coagulation profile using ROTEM. HC745+LC high dose (4:1) and HCHL+LC high dose (4:1) are those mice that received 5 × 1011 vg/mouse AAV8-HC745+AAV8-LC or AAV8-HCHL+AAV8-LC vector, respectively. HCHL+LC low dose (4:1) and HCHL+LC low dose (9:1) are mice that received 2.5 × 1011 vg/mouse AAV8-HCHL+AAV8-LC vector at a ratio of 4:1 or 9:1, respectively. Initiatison of coagulation was measured as coagulation times (CTs). The clot formation time (CFT) was defined as the time needed to achieve a clot firmness of 20 mm. Results shown as mean ± SEM.