Fig. 9.
SD0006 inhibits paw swelling in rat SCW-induced arthritis. SD0006 was administered from days 10 to 21, then plasma was taken from arthritic rats at various times on day 21 and compound levels were determined as described in Materials and Methods. The number of animals per group was between 4 and 8. Two paw volume observations were taken for each animal. Cmax and AUC were determined from plasmas taken from 3 animals per time point. Inhibition of edema as a function of SD0006 dose (a) or Cmax (b) was determined by a 4-parameter logistical model. ED50 and EC50 determinations were made using Grafit 5(2) software.