Fig. 2.

Behavioral changes in the open-field test. 1 = Sham-operated animals (left SNc intact); 2 = control animals; 3, 4 and 5 = up to 7, 14 and 21 days after administration of lactacystin, respectively. a Total shuttling time (grids) (F = 35.694, p < 0.001). b Total ambulation time (grids) (F = 13.877, p < 0.001). c Total ceasing time (grids) (F = 42.583, p < 0.001). d Number of quarter turns to the left (F = 11.301, p = 0.001 in lactacystin-treated animals) and to the right (F = 15.999, p = 0.001 in lactacystin-treated animal). e Number of resting against the wall with the left forelimb (F = 0.554, p = 0.592 in lactacystin-treated animals) and the right forelimb (F = 7.276, p = 0.006 in lactacystin-treated animals) when standing on hindlimbs. f Number of exploratory activities with left (F = 1.450, p = 0.266 in lactacystin-treated animal) and right (F = 12.286, p = 0.001 in lactacystin-treated animals) trunk closing to box wall in the open-field test.