Fig. 3.

Loss of TH neurons in SNc in response to lactacystin treatment. × 400. a Left SNc after lactacystin treatment. Cell loss measured by counting HE-stained cells was significant compared with the contralateral SNc. b Right SNc after injection of lactacystin into the left SNc: the number of TH-positive neurons was abundant. c SNc in control animals was similar to the right SNc of lactacystin-treated rats. d Left SNc in sham-operated animals: numerous TH-positive neurons may be seen; no difference was found in the neural tissue compared with b and c.