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. Author manuscript; available in PMC: 2009 Dec 9.
Published in final edited form as: J Pharm Biomed Anal. 2007 Jan 12;43(5):1789–1795. doi: 10.1016/j.jpba.2006.12.034

Table 2.

Accuracy of MTX and 7‐OH MTX measured in blank dialysates brain samples when referenced to aCSF

  MTX ng/ml 7‐OH MTX ng/ml MTX ng/ml 7‐OH MTX ng/ml MTX ng/ml 7‐OH MTX ng/ml
             
Dialysate from CSF            
Concentration added 402.2 395.4 25.7 25.3 1.65 1.62
Concentration measured 363.0 406.0 25.5 23.7 1.71 1.53
S.D. (n=3) 2.00 3.46 0.10 0.58 0.17 0.20
CV (%) 0.6 0.9 0.4 2.4 10.0 12.7
Accuracy (%)* 90.2 102.7 99.1 93.9 104.0 94.7
             
Dialysate from brain tumor
Concentration added 402.2 395.4 25.7 25.3 1.65 1.62
Concentration measured 359 398.6 25.9 24.4 1.46 1.53
S.D. (n=3) 1.73 1.15 0.70 0.40 0.21 0.13
CV (%) 0.5 0.3 2.7 1.7 14.3 8.5
Accuracy (%) 89.2 100.8 100.9 96.6 88.7 94.3
*

% Accuracy = [concentration measured/concentration added] × 100