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. Author manuscript; available in PMC: 2009 Dec 9.
Published in final edited form as: J Pharm Biomed Anal. 2007 Jan 12;43(5):1789–1795. doi: 10.1016/j.jpba.2006.12.034

Table 3.

Precision and accuracy of MTX and 7‐OH MTX in plasma

  MTX ng/ml 7‐OH MTX ng/ml MTX ng/ml 7‐OH MTX ng/ml MTX ng/ml 7‐OH MTX ng/ml MTX ng/ml 7‐OH MTX ng/ml
                 
Intra‐day (n=6)                
Concentration added 982.4 1985.7 60.5 122.2 11.0 22.2 3.7 7.4
Concentration measured 841.3 1703.3 61.4 137.2 11.4 25.3 3.8 8.3
S.D. 38.7 129.1 4.6 11.3 0.3 0.7 0.3 0.9
CV (%) 4.6 7.6 7.5 8.2 2.4 3.0 9.0 10.4
Bias (%) −14.4 −14.2 1.6 12.3 3.9 14.0 2.8 11.8
                 
Inter‐day (n=6)
Concentration added 982.4 1985.7 60.5 122.2 11.0 22.2 3.7 7.4
Concentration measured 909.7 1922.2 65.3 136.1 12.1 25.4 3.8 8.3
S.D. 45.5 222.0 3.0 6.2 0.4 1.1 0.2 0.3
CV (%) 5.0 11.5 4.5 4.5 3.2 4.4 4.7 4.0
Bias (%) −7.4 −3.2 7.9 11.3 9.9 14.2 4.7 11.4