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Schematic construction of E1-competent adenoviruses. The E1+ recombinant plasmids were used to create replication competent viruses containing a short version (S-S, covering from −230 to +30 nt) of the survivin promoter. RGD modification was incorporated into the fiber region of the adenoviral backbone for further rescue of integrin-dependent competent vectors (AdRGD and CRAd-S-RGD).
