Table II.

Adenovirus mediated regulation of gene expression in human glioma cells.

				Agent/fold
No.	Symbol	Genbank	Description	AdWT	CRAd-S-RGD
1	APAF1 (Apoptotic protease activating factor)	NM_001160	ATP binding, protein binding, regulation of apoptosis, cytosol, intracellular, caspase activation via cytochrome c, neurogenesis, caspase activator activity	1.02	1.41
2	BAD (BCL2-antagonist of cell death)	NM_004322	Apoptosis, induction of programmed cell death	1.02	1.28
3	BAX (BCL2-associtaed X protein)	NM_004324	Integral to membrane, negative regulation of cell cycle, apoptotic mitochondrial changes, induction of apoptosis, regulation of apoptosis, apoptosis, induction of apoptosis by extracellular signals, negative regulation of survival gene product activity	2.17	1.07
4	BIK [BCL2-interacting killer (apoptosis-inducing)]	NM_005426	Integral to membrane, induction of apoptosis, regulation of apoptosis, apoptotic program	0.21	2.26
5	Casp 3 (Caspase 3, apoptosis-related cysteine protease)	NM_004346	Hydrolase activity, proteolysis and peptidolysis, induction of apoptosis, apoptosis, caspase activity, cysteine-type peptidase activity	1.43	1.12
6	TP53 (Tumor protein p53)	NM_000546	Regulation of transcription, DNA-dependent, protein binding, negative regulation of cell cycle, apoptosis, mitochondrion, transcription factor activity, Zinc ion binding, DNA damage response, signal transduction resulting in induction of apoptosis, cell cycle arrest, nucleolus, cell cycle checkpoint, DNA strand annealing activity, copper ion binding, nuclease activity, DNA recombination, base-excision repair, caspase activation via cytochrome c, negative regulation of cell growth, nucleotide-excision repair, regulation of mitochondrial membrane permeability, protein tetramerization, activity negative regulation of helicase activity	0.98	1.36