Figure 3.

MUC4 expression is consistently suppressed in the normal-to-tumor transition. (a) Lysates from eight patient-matched normal and tumor tissue samples, four representing grade II tumors and four representing grade III tumors, were immunoblotted with 1G8s and anti-actin (right panels). Pathology analysis of patient tumor samples, including estrogen receptor (ER), progesterone receptor (PR) and human eipdermal growth factor receptor (HER) 2 status, are provided in the table. (b) Lysates from six independent patient-matched normal and tumor tissues were analyzed side by side with JIMT-1 cell lysates.