Table 1.
Muc4 expression in human breast tissue by immunohistochemistry with 1G8s. Tissue samples from normal breast tissue, primary tumors or lymph node metastases were assigned a value of 0 to 3+ based on their MUC4 staining intensity with 1G8s. Statistical analysis of MUC4 staining intensities is presented for individual samples (upper panel) and patient-matched samples (lower panel).
| Tissue type - individual | Number of cases (%)a | Composite score (mean ± standard error) | P value Norm vs Prim | P value Prim vs Met |
|---|---|---|---|---|
| Normal | 110 (92.4) | 2.01 ± 0.09 | < 0.001 | |
| Hyperplastic | 26 (100) | |||
| Ductal carcinoma in situ | 14 (85.7) | |||
| Primary tumorb | 264 (79.5) | 1.30 ± 0.06 | ||
| Primary lobular carcinoma | 22 (68.1) | |||
| Metastasis | 48 (84) | 1.63 ± 0.15 | 0.033 | |
| Tissue type - paired | Number of pairs | Composite score (mean ± standard error) | P values McNemar's test | |
| Normal with matched primary | 73 | < 0.001 | ||
| Normal | 2.07 ± 0.10 | |||
| Primary | 1.28 ± 0.12 | |||
| Primary with matched metastasisc | 43 | 0.0025 | ||
| Primary | 1.10 ± 0.21 | |||
| Metastasis | 1.95 ± 0.41 |
a. Percent of patient samples that had 1+ stain or greater on a scale from 0 to 3+.
b. Primarily consists of invasive ductal carcinoma-NOS, but also includes invasive lobular carcinoma, micropapillary and mucinous carcinomas.