Table 3.
Significant associations between the presence of DTC, serum DNA yields, LOH frequencies at the microsatellite markers and established risk factors determined by the Mann and Whitney-U test
| Elevated serum DNA |
§LOH complete |
§LOH at D3S1255 |
§LOH at D9S171 pos |
$DTC | |
|---|---|---|---|---|---|
| Age | |||||
| < 55 years | |||||
| > 55 years | no | no | no | P = 0.05 | no |
| Tumor size | |||||
| pT1 | |||||
| pT2-4 | no | no | no | P < 0.05 | no |
| Nodal status | |||||
| pN0 | |||||
| pN1-2 | no | no | no | no | no |
| Metastasis | |||||
| M0 | |||||
| M1 | no | no | no | no | P < 0.05 |
| Histology | |||||
| Ductal | |||||
| Lobular | P < 0.03 | P = 0.05 | no | no | no |
| others | |||||
| Grading | |||||
| I-II | |||||
| III | no | P = 0.006 | no | no | no |
| $DTC | |||||
| Positive | P < 0.05 | no | no | no | |
| Negative | |||||
| Recurrence | no | no |
P
< 0.05 P = 0.009* |
P
< 0.02 P = 0.001 |
no |
*Log rank test
§ loss of heterozygosity (LOH) detected in blood
$ disseminated tumor cells (DTC) detected in bone marrow