Table 3.
Noncompartmental pharmacokinetic parameters for AS1402 after i.v. administration (mean ± SD)
| Dose cohort | 1 mg/kg (n = 3) |
3 mg/kg (n = 9) |
9 mg/kg (n = 6) |
16 mg/kg (n = 8) |
|---|---|---|---|---|
| Cmax (μg/ml) |
21.1 ± 4.67 | 73.5 ± 11.8 | 209 ± 17.3 | 514 ± 232 |
| Half-life (h) | 147 ± 19.3 | 128 ± 50.6 | 111 ± 23.0 | 102 ± 22.6 |
| AUC0-∞(μg*h/ml) | 2,399 ± 1,205 | 9,032 ± 3,314 | 24,757 ± 3,625 | 49,302 ± 10,971 |
| CL (ml/h/kg) | 0.486 ± 0.213 | 0.386 ± 0.174 | 0.369 ± 0.0488 | 0.337 ± 0.0648 |
| Vss (ml/kg) | 68.2 ± 16.9 | 54.6 ± 12.2 | 56.8 ± 7.14 | 50.3 ± 18.56 |