Table 1.

In vivo toxicity study of BU-32 compared with Bortezomib

	Untreated control	BU-32		Bortezomib
		0.1 mg/kg	0.25 mg/kg	0.1 mg/kg	0.25 mg/kg
Total number of mice/group	10	10	10	10	10
Week 1	10	10	10	10	9
Week 2	10	10	8	8	1

Ten mice in each group were treated twice a week for 2 weeks with vehicle (control) or with 0.1 and 0.25 mg/kg BU-32 and Bortezomib. BU-32-treated mice showed more tolerance than Bortezomib at higher dose (0.25 mg/kg), and the lower dose of BU-32 (0.1 mg/kg) was completely safe to the animals after 2 weeks of treatment.