Table 2.
LD blocka | SNP | Genotype | n | Hazard ratio | 95% confidence interval | P for trend | |
---|---|---|---|---|---|---|---|
IRS1 | 1 | rs1801278 | GG | 990 | |||
GA, AA | 115 | 0.82 | 0.58, 1.17 | ||||
1 | rs13306465 | GG | 999 | ||||
GA, AA | 97 | 1.44 | 1.07, 1.94 | ||||
1 | rs1801123 | AA | 823 | ||||
AG, GG | 279 | 1.37 | 1.11, 1.69 | ||||
IGF1R | 11 | rs8038415 | CC | 281 | |||
CT | 536 | 1.11 | 0.88, 1.41 | ||||
TT | 270 | 1.40 | 1.07, 1.83 | 0.015 | |||
11 | rs17847201 | GG | 350 | ||||
GA | 581 | 0.87 | 0.69, 1.10 | ||||
AA | 154 | 0.77 | 0.56, 1.05 | 0.091 |
IRS1, insulin-like growth factor receptor substrate 1; IGF1R, insulin-like growth factor-1 receptor. aLinkage disequilibrium (LD) block was defined by pairwise LD coefficient D' ≥ 0.90.