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Effects of PD 0332991 on cell cycle. (a) Sensitive cell lines (IC50 < 150 nM) show marked G0/G1 arrest and a decrease in the S-phase fraction as compared with (b) resistant cell lines (IC50 > 1,000 nM) after incubation with 100 nM PD 0332991 for 24 hours. Solid bars, control samples; hatched bars, treated samples. Error bars represent the standard error for two separate experiments.
