. 2009 Oct 29;11(5):R77. doi: 10.1186/bcr2419

Table 1.

Cell lines arranged from most sensitive (low IC₅₀) to least sensitive (high IC₅₀)

Cell line	IC₅₀value (nM)	IC₅₀standard error	Breast cancer subtype	ER status	HER2 status
MDA-MB-175	4	0.4	Luminal	Positive	Normal
ZR-75-30	5	0.5	Luminal	Positive	Amplified
CAMA-1	8	0.4	Luminal	Positive	Normal
MDA-MB-134	13	1.3	Luminal	Positive	Normal
HCC-202	21	2.3	Luminal	Positive	Amplified
UACC-893	24	1.6	Luminal	Positive	Amplified
EFM-19	27	12.3	Luminal	Positive	Normal
SUM-190	28	1.3	Luminal	Positive	Amplified
EFM-192A	42	21.2	Luminal	Positive	Amplified
MDA-MB-361	44	4.1	Luminal	Positive	Amplified
HCC-1500	45	22.6	Luminal	Positive	Normal
HCC-1419	51	3.7	Luminal	Positive	Amplified
HCC-38	64	14.8	Basal	Negative	Normal
MDA-MB-415	64	6.6	Luminal	Positive	Normal
MCF-10A	92	0.1	n/a	Negative	Immortalized
UACC-812	96	4.6	Luminal	Positive	Amplified
HCC-2218	100	17.0	Luminal	Positive	Amplified
ZR-75-1	110	54.1	Luminal	Positive	Normal
MDA-MB-453	115	1.4	Luminal	Negative	Amplified
184A1	118	2.0	n/a	Negative	Immortalized
T47-D	127	15.0	Luminal	Positive	Normal
MCF-7	148	25.7	Luminal	Positive	Normal
BT-20	177	3.1	Basal	Negative	Normal
MDA-MB-435	201	7.5	Post-EMT	Negative	Normal
BT-474	240	64.5	Luminal	Positive	Amplified
SK-BR-3	300	83.0	Luminal	Negative	Amplified
KPL-1	327	64.3	Luminal	Positive	Normal
HCC-1143	359	99.7	Basal	Negative	Normal
MDA-MB-231	432	16.1	Post-EMT	Negative	Normal
HCC-1395	472	39.8	Post-EMT	Negative	Normal
SUM-225	503	55.7	Luminal	Negative	Amplified
Hs578t	524	12.3	Post-EMT	Negative	Normal
184B5	538	41.1	n/a	Negative	Immortalized
UACC-732	744	14.9	Luminal	Positive	Amplified
CAL-51	905	0.0	Post-EMT	Negative	Normal
BT-549	1,000	n/a	Post-EMT	Negative	Normal
COLO-824	1,000	n/a	Basal	Negative	Normal
DU4475	1,000	n/a	Basal	Negative	Normal
HCC-1187	1,000	n/a	Basal	Negative	Normal
HCC-1569	1,000	n/a	Post-EMT	Negative	Amplified
HCC-1806	1,000	n/a	Basal	Negative	Normal
HCC-1937	1,000	n/a	Post-EMT	Negative	Normal
HCC-1954	1,000	n/a	Basal	Negative	Amplified
HCC-70	1,000	n/a	Basal	Negative	Normal
MDA-MB-436	1,000	n/a	Post-EMT	Negative	Normal
MDA-MB-157	1,000	n/a	Post-EMT	Negative	Normal
MDA-MB-468	1,000	n/a	Basal	Negative	Normal

Included are molecular subtype and estrogen receptor (ER) and HER2 status. Cell lines representing the luminal ER-positive subtype were most sensitive to the growth inhibition effects of PD 0332991. n/a, not applicable; Post-EMT, cell lines classified as representing breast cancers that had undergone an epithelial-to-mesenchymal transition.