Table 1.
Genes/SNPs associated with PsA. Numbers of cases/controls used for each study along with corresponding odds ratios (ORs) and P values are shown.
Gene | Chs | SNP | Case | Control | OR | P | Ref |
---|---|---|---|---|---|---|---|
IL12B | 5q33 | rs6887695 | 576 | 480 | 1.1 | 0.0013 | 60 |
748 | 937 | 1.5 | 4.72 × 10−7 | 133 | |||
rs3212227 | 748 | 937 | 1.48 | 2.1 × 10−5 | 133 | ||
IL23R | 1p31 | rs11209026 | 576 | 480 | 1.70 | 8 × 10−4 | 60 |
748 | 937 | 1.59 | 0.002 | 133 | |||
IL2/IL21 | 4q27 | rs13151961 | 576 | 480 | 1.37 | 0.002 | 60 |
IL-1 gene cluster | 2q13 | rs3811047 | 212 | 159 | 1.82 | 127 | |
TNF-alpha | 6p21 | −857 | 375 | 376 | 1.96 | 0.0025 | 67 |
HLA class I6p21 rs10484554 | 576 | 480 | 2.4 | 6.9 × 10−11 | 60 | ||
6p21 | HLA-Cw6 | 94 | 48 | ||||
HLA class I - HCP5 | 6p21 | rs2395029 | 576 | 480 | 3.2 | 1.9 × 10−10 | 60 |
Killer inhibitory receptor (2DS1 and/or 2DS2) + HLA-Cw ligand group homozygosity | 19q/6p21 | 366/75 | P < 0.0001 | 68–70 |