Figure 3.

Models for the distributions of LOI in single cells. Simulations of single cell LOI distributions in 2000 cells were presented as histograms of cell counts with different percentage of LOI. The format for data presentation is the same as in Figure 2. (A) In the all-or-none model, we defined two distinct populations of cells: fully imprinted or having completely lost imprinting in the minor allele. In the partial LOI model, the transcription of the minor allele is less efficient than the major allele in each cell. (B) Simulated LOI distributions in single cells for each model (left side: all-or-none model; right side: partial LOI model).