FIGURE 5.
Acidic pHi potentiates the activity of ΔR-S660A-CFTR. A, representative recordings show the effects of pHi on the activity of a single ΔR-S660A-CFTR Cl− channel. Dotted lines indicate where the channel is closed, and downward deflections correspond to channel openings. B, C, and D, effects of pHi on the Po, MBD, and IBI of ΔR-S660A (columns) and wild-type CFTR (circles). Data are means ± S.E. (B, n = 6 for all data; C and D, ΔR-S660A-CFTR, n = 3; wild-type-CFTR, n ≥ 6); asterisks indicate ΔR-S660A-CFTR values that are significantly different from the pHi 7.3 control (p < 0.05).