FIGURE 5.

Schematic diagram of regulation of Bcr by TG2. Left, in the presence of guanine nucleotides, TG2 is in a closed conformation with the catalytic core domain masked by the β1/β2 domains and unable to interact with Bcr, which is shown as in the process of binding GTP-bound Rac. Right, TG2 that is not bound to guanine nucleotides or is in the presence of calcium has an open conformation with the C-terminal β1 and β2 barrels not in contact with the catalytic core domain (28, 29). The catalytic core domain can bind to Bcr molecules that have hydrolyzed and released GDP-bound Rac.