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. 2009 Oct 14;284(51):35839–35849. doi: 10.1074/jbc.M109.057273

FIGURE 1.

FIGURE 1.

Analysis of the cardiac phenotype in control and LKB1-KO mice at 4 and 12 weeks of age. A, gross appearance of the isolated hearts (top) and long axis section of four-chamber view with Masson's trichrome staining (middle). The mean atrial and ventricular weight to body weight ratios are also shown (bottom). B, histological sections of Masson's trichrome-stained left atrial and left ventricular tissue (upper). The mean atrial and ventricular myofibrillar transverse diameter in control (open bars) and LKB1-KO (filled bars) mice (lower) are shown. Values are expressed as mean ± S.E. **, p < 0.01; each group n = 5–7. C, mRNA level of collagen I and III expression in atria and ventricles of control and LKB1-KO mice. The real time PCR analyses were performed in control (open bars) and LKB1-KO (filled bars) at 4 and 12 weeks of age, respectively. Values are change relative to each control band (4-week-old control atria) and are expressed as mean ± S.E. **, p < 0.01; n = 6 in each group.