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. 2009 Oct 14;284(51):35839–35849. doi: 10.1074/jbc.M109.057273

FIGURE 2.

FIGURE 2.

Direct and indirect measures of cardiac dysfunction in LKB1-KO mice at 4 and 12 weeks of age. A, representative echocardiogram. Serial changes of B-mode of parasternal long axis view and M-mode of left ventricular short axis view in control and LKB1-KO mice are shown. B, echocardiographic measurements of left atrial dimension (LA), left ventricular diastolic dimension (LVDd), and fractional shortening (FS) between 4- and 12-week-old control and LKB1-KO mice. *, p < 0.05; **, p < 0.01 versus age-matched control; n = 8 in each sample. NS, not significant. C, invasive analysis of cardiac function with Miller catheter in both 4- and 12-week-old control and LKB1-KO mice. Values are expressed as mean ± S.E. *, p < 0.05; **, p < 0.01. Each group n = 8. BP, blood pressure. D, mRNA and protein expression of phospholamban and SERCA2. The real time PCR or Western blot analyses were performed in control (open bars) and LKB1-KO (filled bars) at 4 and 12 weeks of age, respectively. Values are change relative to each control band (4-week-old control atria) and are expressed as mean ± S.E. *, p < 0.05; **, p < 0.01; n = 6–8 in each group.

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