Table 2. Genotype frequencies of eight SNPs in TLR4. Patients with sarcoid uveitis compared to those with sarcoid non-uveitis.
| dbSNP | Alleles (Maj/Min) | Subjects | Genotype frequency n (%) | Minor allele dominance (Maj/Min + Min/Min) | ||||
|---|---|---|---|---|---|---|---|---|
| Maj/Maj | Maj/Min | Min/Min | p (SUvs.SN)* | p (SUvs.SN)** | OR (95%CI) | |||
| rs10759930 | T/C | SU | 77 (39.3) | 95 (48.5) | 24 (12.2) | 0.297 | 0.885 | 0.94 (0.41-2.14) |
| SN | 11 (40.7) | 10 (37.0) | 6 (22.2) | |||||
| rs1927914 | A/G | SU | 78 (39.8) | 94 (48.0) | 24 (12.2) | 0.306 | 0.925 | 0.96 (0.42-2.18) |
| SN | 11 (40.7) | 10 (37.0) | 6 (22.2) | |||||
| rs1927911 | G/A | SU | 81 (41.3) | 92 (46.9) | 23 (11.7) | 0.586 | 0.954 | 1.02 (0.45-2.32) |
| SN | 11 (40.7) | 11 (40.7) | 5 (18.5) | |||||
| rs12377632 | C/T | SU | 79 (40.3) | 94 (48.0) | 23 (11.7) | 0.567 | 0.966 | 0.98 (0.43-2.23) |
| SN | 11 (40.7) | 11 (40.7) | 5 (18.5) | |||||
| rs2149356 | G/T | SU | 81 (41.3) | 92 (46.9) | 23 (11.7) | 0.586 | 0.954 | 1.02 (0.45-2.32) |
| SN | 11 (40.7) | 11 (40.7) | 5 (18.5) | |||||
| rs11536889 | G/C | SU | 117 (59.7) | 66 (33.7) | 13 ( 6.6) | 0.812 | 0.966 | 1.02 (0.45-2.31) |
| SN | 16 (59.3) | 10 (37.0) | 1 (3.7) | |||||
| rs7037117 | A/G | SU | 115 (58.7) | 75 (38.3) | 6 (3.1) | 0.594 | 0.300 | 1.53 (0.68-3.43) |
| SN | 13 (48.1) | 13 (48.1) | 1 (3.7) | |||||
| rs7045953 | A/G | SU | 165 (84.2) | 29 (14.8) | 2 (1.0) | 0.755 | 0.598 | 0.67 (0.19-2.35) |
| SN | 24 (88.9) | 3 (11.1) | 0 (0.0) | |||||
In the table, SNP represents single-nucleotide polymorphism, TLR4 represents toll-like receptor 4, Maj represents major allele, Min represents minor allele, SU represents sarcoid uveitis, and SN represents sarcoid non-uveitis. The asterisk indicates the data was calculated with the χ2 test using a 3×2 contingency table. The double asterisk indicates the data was calculated with the χ2 test using a 2×2 contingency table.