Table 3. Genotype frequencies of eight SNPs in TLR4. Patients with sarcoid uveitis compared to control subjects.
| dbSNP | Alleles (Maj/Min) | Subjects | Genotype frequency n (%) | Minor allele dominance (Maj/Min + Min/Min) | ||||
|---|---|---|---|---|---|---|---|---|
| Maj/Maj | Maj/Min | Min/Min | p (SUvs.C)* | p (SUvs.C)** | OR (95%CI) | |||
| rs10759930 | T/C | SU | 77 (39.3) | 95 (48.5) | 24 (12.2) | 0.493 | 0.915 | 0.98 (0.66-1.46) |
| C | 82 (39.8) | 91 (44.2) | 33 (16.0) | |||||
| rs1927914 | A/G | SU | 78 (39.8) | 94 (48.0) | 24 (12.2) | 0.535 | 0.922 | 1.02 (0.72-2.44) |
| C | 81 (39.3) | 92 (44.7) | 33 (16.0) | |||||
| rs1927911 | G/A | SU | 81(41.3) | 92 (46.9) | 23 (11.7) | 0.318 | 0.756 | 1.07 (0.72-1.59) |
| C | 82 (39.8) | 89 (43.2) | 35 (16.7) | |||||
| rs12377632 | C/T | SU | 79 (40.3) | 94 (48.0) | 23 (11.7) | 0.440 | 0.919 | 1.02 (0.69-1.52) |
| C | 82 (39.8) | 91 (44.2) | 33 (16.0) | |||||
| rs2149356 | G/T | SU | 81 (41.3) | 92 (46.9) | 23 (11.7) | 0.464 | 0.682 | 1.09 (0.78-2.65) |
| C | 81 (39.3) | 92 (44.7) | 33 (16.0) | |||||
| rs11536889 | G/C | SU | 117 (59.7) | 66 (33.7) | 13 ( 6.6) | 0.617 | 0.327 | 1.22 (0.82-1.81) |
| C | 113 (54.9) | 78 (37.9) | 15 (7.3) | |||||
| rs7037117 | A/G | SU | 115 (58.7) | 75 (38.3) | 6 (3.1) | 0.066 | 0.312 | 0.81 (0.54-1.21) |
| C | 13 (63.6) | 61 (29.6) | 14 (6.8) | |||||
| rs7045953 | A/G | SU | 165 (84.2) | 29 (14.8) | 2 (1.0) | 0.582# | 0.485 | 1.20 (0.72-2.03) |
| C | 168 (81.6) | 37 (18.0) | 1 (0.5) | |||||
In the table, SNP represents single-nucleotide polymorphism, TLR4 represents toll-like receptor 4, Maj represents major allele, Min represents minor allele, SU represents sarcoid uveitis, and C represents control subjects. The asterisk indicates the data was calculated with the χ2 test using a 3×2 contingency table. The double asterisk indicates the data was calculated with the χ2 test using a 2×2 contingency table. The sharp (hash mark) indicates the data was calculated with Fisher's Exact Test.