Figure 5. Juxtaposition of changes in atomic fluctuations with increases in residue solvent-accessible surface area (SASA).

Atomic fluctuations, plotted as gray lines with filled circles, were computed for backbone C_α atoms from the solution phase trajectory data as in Figure 4. Differences in the magnitudes of these fluctuations and those collected from the cryo-solvated lattice simulation are plotted as red lines. Changes in SASA resulting from taking the streptavidin tetramer out of the lattice and into solution are superimposed as black bars.