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. Author manuscript; available in PMC: 2010 Dec 2.
Published in final edited form as: J Am Chem Soc. 2009 Dec 2;131(47):17087–17089. doi: 10.1021/ja907924j

Scheme 6. Intramolecular Ru-catalyzed alkene-alkyne couplinga.

Scheme 6

aConditions: (a) 5, KHMDS, 18-crown-6, THF, E/Z = 1/5, 62% (50% isolated Z-isomer); (b) 5 mol% [CpRu(CH3CN)3]PF6, acetone (c 0.001 M), 50 °C, 15 min, 99%; (c) PPTS, tert-BuOH, 66%.