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TST positivity is associated with downregulation of antigen-specific IL-17 and IL-23. PBMC from TST+ (n = 15) and TST− (n = 10–15) patients were stimulated with PPD (10 μg/ml), Mtb CFA (10 μg/ml), or anti-CD3 (5 μg/ml) for 24 h, and IL-17, IL-23, IL-6, and IL-1β cytokine levels were measured by ELISA. Results are shown as net cytokine production over media control. P values were calculated using the Mann-Whitney test and only statistically significant P values are shown.
