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. 2009 Dec 21;4(12):e8380. doi: 10.1371/journal.pone.0008380

Figure 5. Inflammatory cytokine levels in tissue homogenates of tail skin.

Figure 5

Median fluorescence intensity was used to assess the relative tissue concentrations of MCP-1, MCP-3, MIP1a, Eotaxin, and VEGF-A. MCP-1 levels were elevated in mice with lymphedema (LY) and further increased by both ketoprofen and sTNF-R1 anti-inflammatory treatments. MCP-3 levels were also elevated in lymphedema but were significantly reduced by both treatments. A similar pattern was observed for macrophage inflammatory protein 1a (MIP1a). Like TNF-α, eotaxin levels were reduced by NSAID therapy and decreased by sTNF-R1. No effect on the blood vascular growth factor VEGF-A was observed. *P<0.04 vs to LY, † P = 0.05 vs LY, ‡ P<0.05 vs LY-NSAID.